Investigating how the immune system responds to SARS-CoV-2 in the nose
Innate immune responses to SARS-CoV-2 infection in the olfactory epithelium
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA AT DAVIS · NIH-11061378
This study is looking at how the immune system in your nose reacts to the virus that causes COVID-19, especially how it affects your sense of smell, to help understand why some people lose their smell during and after the illness.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA AT DAVIS (nih funded) |
| Locations | 1 site (DAVIS, UNITED STATES) |
| Trial ID | NIH-11061378 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how the immune system reacts to SARS-CoV-2 infection specifically in the olfactory epithelium, which is responsible for our sense of smell. It aims to explore the role of certain supporting cells in the nose that may allow the virus to enter and cause inflammation. By studying these immune responses and the effects on olfactory sensory neurons, the research seeks to uncover the mechanisms behind the loss of smell often seen in COVID-19 patients. The findings could help identify potential long-term neurological impacts related to olfactory dysfunction after COVID-19.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who have experienced sudden loss of smell following a COVID-19 infection.
Not a fit: Patients who have not had COVID-19 or do not experience olfactory dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for patients experiencing olfactory loss due to COVID-19.
How similar studies have performed: While there has been some research on COVID-19 and olfactory loss, this specific investigation into the immune response in the olfactory epithelium is relatively novel.
Where this research is happening
DAVIS, UNITED STATES
- UNIVERSITY OF CALIFORNIA AT DAVIS — DAVIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GONG, QIZHI — UNIVERSITY OF CALIFORNIA AT DAVIS
- Study coordinator: GONG, QIZHI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: after COVID-19 infection, after infection by SARS-CoV-2, after SARS-CoV-2 infection, after SARS-CoV2 infection, after severe acute respiratory distress syndrome CoV-2 infection