Investigating how the immune system interacts in Alzheimer's disease
Official title: The adaptive-innate immune interactome across multiple tissues in Alzheimer's disease
Funded at Icahn School of Medicine at Mount Sinai · NIH-11013396 · Data updated 2026-11-12
This study is looking at how different parts of the immune system work together in people with Alzheimer's disease to understand how they affect brain health and aging, with the hope of finding new ways to help treat the condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | May 15, 2023 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $1,969,360 |
| NIH project number | 5R01AG082185-03 |
| Project ID | NIH-11013396 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those at risk of developing it.
✕Less likely to help
Patients with other forms of dementia unrelated to Alzheimer's disease may not benefit from this research.
What this research studies
This research explores the roles of both the innate and adaptive immune systems in Alzheimer's disease, focusing on how they interact and affect brain aging and neurodegeneration. By analyzing immune cells from brain tissue and blood samples of patients, the study aims to uncover changes in immune cell types and their implications for Alzheimer's pathology. The research utilizes advanced techniques like single cell profiling to gain insights into the immune response at different stages of the disease, which could lead to new therapeutic strategies.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that target immune system interactions to slow down or prevent the progression of Alzheimer's disease.
How similar studies have gone: While the role of the innate immune system in Alzheimer's has been studied, the specific interactions with adaptive immunity are less explored, making this research a novel approach.
Where this research is happening
-
Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Roussos, Panagiotis — Icahn School of Medicine at Mount Sinai
- Study coordinator: Roussos, Panagiotis
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.