Investigating how the immune system clears hepatitis B virus
Official title: Immune analysis of the HBsAg seroclearance response terminating chronic HBV
Funded at University of California, San Francisco · NIH-11025101 · Data updated 2026-11-12
This study is looking at how the immune system helps get rid of the hepatitis B virus in people with chronic hepatitis B, using mouse models to find out what works best, which could help develop better treatments for patients like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | November 20, 2024 |
| Project end | October 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $814,790 |
| NIH project number | 1R01AI187598-01 |
| Project ID | NIH-11025101 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults with chronic hepatitis B who have been on antiviral therapy and are considering stopping treatment.
✕Less likely to help
Patients who are not infected with hepatitis B or those who have already achieved HBsAg clearance may not benefit from this research.
What this research studies
This research focuses on understanding the immune response that leads to the clearance of the hepatitis B surface antigen (HBsAg) in patients with chronic hepatitis B virus (HBV) infection. By using mouse models that mimic human HBV infection, the study aims to identify the immune mechanisms that promote HBsAg clearance. The research will analyze liver and blood samples from patients who have undergone antiviral therapy to determine the factors that contribute to successful immune responses against HBV. This could lead to new therapeutic strategies for patients struggling with chronic HBV.
Why it matters
Potential benefit: If successful, this research could provide new insights and therapies that enable more patients to achieve a clinical cure for chronic hepatitis B.
How similar studies have gone: Previous studies have shown promising results in understanding immune responses in hepatitis B, indicating that this approach has potential for success.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Baron, Jody L — University of California, San Francisco
- Study coordinator: Baron, Jody L
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.