Investigating how the immune system affects lung transplant outcomes
Complement driven innate and adaptive autoreactivity in lung transplantation
This study is looking at how the immune system might cause problems after a lung transplant in people with emphysema, using mice to learn more about how certain antibodies and T cells can affect recovery, with the hope of finding better ways to help lung transplant patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project ID | NIH-10363208 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of autoimmunity in lung transplant rejection, particularly in patients with emphysema. By using mouse models, the study aims to explore how pre-existing autoreactive antibodies and T cells may contribute to complications like obliterative bronchiolitis after transplantation. The researchers will examine the mechanisms of injury that occur during the transplant process, specifically looking at how immune responses can exacerbate damage to the transplanted lung. The findings could lead to better strategies for managing immune responses in lung transplant recipients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with emphysema who are considering or have undergone lung transplantation.
Not a fit: Patients who do not have emphysema or are not candidates for lung transplantation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved long-term outcomes for lung transplant patients by identifying ways to mitigate immune-related complications.
How similar studies have performed: Other research has indicated that understanding immune responses in transplant settings can lead to significant improvements in patient outcomes, suggesting that this approach has potential for success.
Where this research is happening
Gainesville, United States
- University of Florida — Gainesville, United States (Active)
Researchers
- Principal investigator: Atkinson, Carl — University of Florida
- Study coordinator: Atkinson, Carl
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.