Investigating how the immune environment and gut bacteria influence early colon cancer development
Shaping of the Microenvironment in Colonic Pre-Cancer by Epithelia and Microbiota
This study is looking at how certain changes in the gut, like pre-cancerous growths, might lead to colon cancer, and it’s inviting patients to help explore how immune cells and gut bacteria play a role in this process to find ways to prevent cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project ID | NIH-10926848 on NIH RePORTER |
What this research studies
This research focuses on understanding the early stages of colon cancer, specifically two types of pre-cancerous lesions: adenomas and sessile serrated lesions. By examining how immune cells and gut bacteria interact with these lesions, the study aims to uncover the biological mechanisms that lead to cancer progression or stability. Patients may be involved in prospective studies that explore the relationship between specific bacteria and the development of these lesions, providing insights into potential preventive strategies.
Who could benefit from this research
Good fit: Ideal candidates for participation are individuals with a history of colon polyps or those at high risk for colon cancer.
Not a fit: Patients without any history of colon polyps or those not at risk for colon cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention strategies for colon cancer by identifying key factors that influence pre-cancer progression.
How similar studies have performed: Other research has shown promising results in understanding the role of the microbiome in cancer development, suggesting that this approach could yield valuable insights.
Where this research is happening
Nashville, United States
- Vanderbilt University Medical Center — Nashville, United States (Active)
Researchers
- Principal investigator: Shrubsole, Martha J. — Vanderbilt University Medical Center
- Study coordinator: Shrubsole, Martha J.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.