Investigating how the hormone FGF21 helps protect the liver from alcohol damage
Coordinate Regulation of an Alcohol Protective Response by the Liver-derived Hormone FGF21
['FUNDING_R01'] · UT SOUTHWESTERN MEDICAL CENTER · NIH-10893347
This study is looking at how a hormone from the liver called FGF21 can help reduce the negative effects of drinking alcohol, like liver damage and dehydration, and it’s using specially modified mice to find out how it works, with hopes of discovering new ways to help people who struggle with alcohol use.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UT SOUTHWESTERN MEDICAL CENTER (nih funded) |
| Locations | 1 site (DALLAS, UNITED STATES) |
| Trial ID | NIH-10893347 on ClinicalTrials.gov |
What this research studies
This research explores the role of the liver-derived hormone FGF21 in mitigating the harmful effects of alcohol consumption. It focuses on how FGF21 influences brain activity to reduce alcohol intake and promote hydration. The study employs genetically-engineered mouse models to understand the mechanisms by which FGF21 protects against alcohol-induced liver injury and hypothermia. By examining these processes, the research aims to identify potential new treatments for alcohol abuse and related diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who consume alcohol excessively and may be at risk for alcohol-related liver diseases.
Not a fit: Patients who do not consume alcohol or have no history of alcohol-related health issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic options for individuals struggling with alcohol abuse and its associated health complications.
How similar studies have performed: Previous research has shown promise in using hormones like FGF21 for metabolic diseases, suggesting potential for success in this novel application.
Where this research is happening
DALLAS, UNITED STATES
- UT SOUTHWESTERN MEDICAL CENTER — DALLAS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KLIEWER, STEVEN A. — UT SOUTHWESTERN MEDICAL CENTER
- Study coordinator: KLIEWER, STEVEN A.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alcoholic Liver Diseases