Investigating how the heart develops its shape during early embryonic stages
Understanding Cardiac C-Looping Using Microscale In Vitro Models
This study is looking at how the heart takes on its important c-shape during early development, which is key for making sure our bodies are balanced left and right, and it aims to help us understand what goes wrong when this process doesn't happen correctly, potentially leading to heart defects.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rensselaer Polytechnic Institute NIH-funded |
| Lab location | 1 site (Troy, United States) |
| Project ID | NIH-11090933 on NIH RePORTER |
What this research studies
This research focuses on understanding how the embryonic heart forms its characteristic c-shape, which is crucial for proper left-right body symmetry. By using advanced techniques such as micro-fabrication and 3D hydrogels, the study aims to explore the cellular mechanisms that lead to heart looping and how disruptions in this process can result in serious birth defects. The research involves live-cell imaging and genetic mouse models to observe and manipulate heart cell behavior, providing insights into the fundamental biology of heart development.
Who could benefit from this research
Good fit: Ideal candidates for this research are expectant parents with a family history of congenital heart defects or those who have had previous pregnancies affected by such conditions.
Not a fit: Patients with congenital heart defects that are not related to the mechanisms being studied may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating congenital heart defects in newborns.
How similar studies have performed: Other research has shown promise in understanding cardiac development through similar innovative approaches, indicating a potential for success in this area.
Where this research is happening
Troy, United States
- Rensselaer Polytechnic Institute — Troy, United States (Active)
Researchers
- Principal investigator: Wan, Leo Q. — Rensselaer Polytechnic Institute
- Study coordinator: Wan, Leo Q.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.