Investigating how the gut environment and genetics influence the progression of colon adenomas to colorectal cancer
Understanding adenoma progression: Interplay among tissue microenvironment, clonal architecture, and gut microbiome
This study is looking at how certain growths in the colon, called adenomas, can turn into colorectal cancer, and it aims to find out why some of these growths become more serious while others don’t, so we can improve ways to prevent and treat this type of cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Fred Hutchinson Cancer Center NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10994009 on NIH RePORTER |
What this research studies
This research focuses on understanding the early stages of colorectal cancer, particularly how colon adenomas, which are precursors to cancer, progress through various biological mechanisms. The study will explore the interplay between the tissue microenvironment, genetic factors, and the gut microbiome to identify why some adenomas progress to advanced stages while others do not. By analyzing samples from patients, researchers aim to uncover the underlying factors that contribute to adenoma development and progression. This could lead to better prevention strategies and targeted treatments for colorectal cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a history of colon adenomas or those at high risk for colorectal cancer.
Not a fit: Patients without any history of colon adenomas or those who do not have risk factors for colorectal cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved methods for preventing colorectal cancer by identifying high-risk individuals and developing targeted interventions.
How similar studies have performed: Previous research has shown promising results in understanding the role of genetic and environmental factors in cancer progression, suggesting that this approach could yield valuable insights.
Where this research is happening
Seattle, United States
- Fred Hutchinson Cancer Center — Seattle, United States (Active)
Researchers
- Principal investigator: Grady, William Mallory — Fred Hutchinson Cancer Center
- Study coordinator: Grady, William Mallory
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.