Investigating how the gut environment and genetics influence the progression of colon adenomas to colorectal cancer
Understanding adenoma progression: Interplay among tissue microenvironment, clonal architecture, and gut microbiome
This study is looking at how early growths in the colon, called adenomas, can turn into colorectal cancer, and it’s for people who have these growths to help find better ways to prevent cancer from developing.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Fred Hutchinson Cancer Center NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10926923 on NIH RePORTER |
What this research studies
This research focuses on understanding the early stages of colorectal cancer, specifically how colon adenomas, which are precursors to cancer, progress to more advanced stages. The study examines the interplay between the tissue microenvironment, genetic changes, and the gut microbiome in individuals with these adenomas. By analyzing various biological markers and patterns, the research aims to identify factors that contribute to the progression of these lesions. This could lead to better prevention strategies and targeted interventions for at-risk patients.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with diagnosed colon adenomas or those with a family history of colorectal cancer.
Not a fit: Patients who do not have any history of colon adenomas or colorectal cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved methods for preventing colorectal cancer by identifying individuals at higher risk based on their adenoma characteristics.
How similar studies have performed: Previous research has shown promising results in understanding the mechanisms of colorectal cancer progression, indicating that this approach could yield valuable insights.
Where this research is happening
Seattle, United States
- Fred Hutchinson Cancer Center — Seattle, United States (Active)
Researchers
- Principal investigator: Grady, William Mallory — Fred Hutchinson Cancer Center
- Study coordinator: Grady, William Mallory
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.