Investigating how the extracellular matrix affects Myelomeningocele
The role of extracellular matrix in Myelomeningocele
This study is looking at how certain substances in the body might cause spinal cord damage in babies with Myelomeningocele, a serious type of Spina Bifida, and it hopes to find ways to reduce this damage during pregnancy to improve outcomes for these little ones.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Temple Univ of the Commonwealth NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10457986 on NIH RePORTER |
What this research studies
This research focuses on Myelomeningocele (MMC), a severe form of Spina Bifida that leads to significant neurological disabilities. The study aims to understand how components of the extracellular matrix, particularly chondroitin sulfate proteoglycans, contribute to spinal cord damage during pregnancy. By using a rat model, researchers will explore the potential of degrading these components to reduce damage and improve neurological outcomes. This could lead to new prenatal treatments that enhance the effectiveness of existing surgical interventions.
Who could benefit from this research
Good fit: Ideal candidates for this research are expectant mothers carrying a fetus diagnosed with Myelomeningocele.
Not a fit: Patients with forms of Spina Bifida other than Myelomeningocele may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved prenatal treatments that reduce disabilities associated with Myelomeningocele.
How similar studies have performed: Previous research has shown promise in using extracellular matrix components to influence spinal cord development, suggesting potential for success in this approach.
Where this research is happening
Philadelphia, United States
- Temple Univ of the Commonwealth — Philadelphia, United States (Active)
Researchers
- Principal investigator: Krynska, Barbara — Temple Univ of the Commonwealth
- Study coordinator: Krynska, Barbara
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.