Investigating how the Epstein-Barr virus contributes to cancer development
Role of EBV Lytic Infection in Viral Tumorigenesis
This study is looking at how a specific phase of the Epstein-Barr virus might help cancer grow, especially in people with certain types of tumors, and it aims to find new ways to treat these cancers using special mouse models.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project ID | NIH-10667423 on NIH RePORTER |
What this research studies
This research focuses on the Epstein-Barr virus (EBV), which is linked to various human cancers, particularly those affecting B cells and epithelial cells. The study aims to understand the role of lytic infection, a phase of the virus's life cycle, in promoting tumor formation. By using humanized mouse models, researchers will explore how lytic viral proteins influence the growth of cancerous cells and the immune response. The findings could provide insights into potential therapeutic targets for EBV-related malignancies.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with EBV-related cancers, such as lymphomas or nasopharyngeal carcinoma.
Not a fit: Patients with cancers not associated with Epstein-Barr virus infection may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for cancers associated with the Epstein-Barr virus.
How similar studies have performed: Previous research has shown promising results in understanding the role of viral infections in cancer, suggesting that this approach could yield valuable insights.
Where this research is happening
Madison, United States
- University of Wisconsin-Madison — Madison, United States (Active)
Researchers
- Principal investigator: Kenney, Shannon Celeste — University of Wisconsin-Madison
- Study coordinator: Kenney, Shannon Celeste
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.