Investigating how the environment around tumors affects breast cancer after pregnancy
The Tumor Microenvironment and Lymphatic Remodeling in Postpartum Breast Cancer
['FUNDING_R01'] · COLUMBIA UNIVERSITY HEALTH SCIENCES · NIH-10977424
This study is looking at how breast cancer that happens after having a baby might be different and more serious, and it aims to find ways to help young women who face this challenge by understanding what happens in the tumor environment during this time.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | COLUMBIA UNIVERSITY HEALTH SCIENCES (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10977424 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding postpartum breast cancer (PPBC), which can be more aggressive and deadly compared to other types of breast cancer. The study examines the tumor microenvironment and how factors like lymphatic remodeling and inflammation during the postpartum period may influence tumor growth and metastasis. By analyzing the immune cells and other elements within the tumor environment, the research aims to identify potential strategies to reduce the risk of PPBC and improve outcomes for affected women. The findings could lead to better risk stratification and treatment options tailored for young women diagnosed with breast cancer after pregnancy.
Who could benefit from this research
Good fit: Ideal candidates for this research are women who have recently given birth and are at risk for postpartum breast cancer.
Not a fit: Patients who are not postpartum or those who have not been diagnosed with breast cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide new insights and strategies to reduce the risk of aggressive breast cancer in women after childbirth.
How similar studies have performed: While there is limited research specifically targeting postpartum breast cancer, studies on tumor microenvironments and immune responses have shown promise in other cancer types.
Where this research is happening
NEW YORK, UNITED STATES
- COLUMBIA UNIVERSITY HEALTH SCIENCES — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MCDONALD, JASMINE ALISE — COLUMBIA UNIVERSITY HEALTH SCIENCES
- Study coordinator: MCDONALD, JASMINE ALISE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.