Investigating how the endothelium contributes to pulmonary hypertension
Endothelium-driven signaling network in the development of pulmonary hypertension
This study is creating a new mouse model to better understand pulmonary hypertension by looking at how certain signals in blood vessel linings can affect cell energy, with the goal of finding new ways to treat this serious lung condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-10646507 on NIH RePORTER |
What this research studies
This research aims to develop a new mouse model of pulmonary hypertension (PH) by focusing on the endothelium, which is the inner lining of blood vessels. The study will explore a specific signaling network involving endothelial nitric oxide synthase (eNOS) and its role in causing stress and dysfunction in mitochondria, which are critical for cell energy. By understanding these mechanisms, the researchers hope to identify new therapeutic targets for treating pulmonary hypertension, a serious condition that affects blood flow in the lungs.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with pulmonary hypertension or those at risk for developing this condition.
Not a fit: Patients with pulmonary hypertension caused by factors unrelated to endothelial dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments for pulmonary hypertension, improving outcomes for patients suffering from this condition.
How similar studies have performed: Previous research has shown promising results in understanding endothelial dysfunction in pulmonary hypertension, suggesting that this approach could yield valuable insights.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Cai, Hua Linda — University of California Los Angeles
- Study coordinator: Cai, Hua Linda
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.