Investigating how the endothelial glycocalyx is affected during sepsis
Endothelial glycocalyx shedding in septic injury
This study is looking at how a protective layer in your blood vessels gets damaged during severe infections like sepsis, and it hopes to find new ways to help treat this condition better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Florida NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project ID | NIH-10987050 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of the endothelial glycocalyx in sepsis, a severe condition caused by infections. The team aims to identify how bacterial infections lead to the shedding of glycocalyx molecules, which may contribute to inflammation and damage in blood vessels. By using advanced techniques like imaging and molecular analysis, the researchers will explore the mechanisms behind this process and its implications for patient health. The goal is to uncover new diagnostic and therapeutic targets that could improve treatment for sepsis.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced sepsis or are at high risk for developing sepsis due to infections.
Not a fit: Patients who do not have a history of sepsis or are not at risk for severe bacterial infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new ways to diagnose and treat sepsis, potentially improving outcomes for patients suffering from this critical condition.
How similar studies have performed: Previous research has shown promising results in understanding the role of the glycocalyx in various inflammatory conditions, suggesting that this approach could yield valuable insights.
Where this research is happening
Tampa, United States
- University of South Florida — Tampa, United States (Active)
Researchers
- Principal investigator: Yuan, Sarah Y — University of South Florida
- Study coordinator: Yuan, Sarah Y
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.