Investigating how the EGF receptor is taken up by cells and its role in signaling
EGF Receptor Endocytosis: Mechanisms and Role in Signaling
This study is looking at how a specific protein called EGFR is taken into cells and how this affects how cells communicate, which could help us understand its role in diseases like cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-11060887 on NIH RePORTER |
What this research studies
This research focuses on understanding the mechanisms by which the epidermal growth factor receptor (EGFR) is internalized by cells and how this process affects cellular signaling. Using advanced single-cell and high-throughput methods, the study aims to monitor the trafficking of gene-edited EGFR in real-time. By examining how stress and other factors influence EGFR endocytosis, the research seeks to clarify the relationship between receptor signaling and cellular responses. This could provide insights into how EGFR functions in various diseases, including cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 years old who may have conditions related to EGFR signaling, such as certain cancers.
Not a fit: Patients who are under 21 years old or do not have conditions related to EGFR signaling may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved therapeutic strategies targeting EGFR-related pathways in diseases such as cancer.
How similar studies have performed: Previous research has shown success in understanding receptor signaling mechanisms, but the specific focus on EGFR endocytosis and its regulatory pathways is relatively novel.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Sorkin, Alexander D — University of Pittsburgh at Pittsburgh
- Study coordinator: Sorkin, Alexander D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.