Investigating how the complement system affects muscle loss in cancer patients
The Complement System and Cancer Cachexia
['FUNDING_R01'] · UNIVERSITY OF FLORIDA · NIH-10898598
This study is looking into how cancer can cause serious weight and muscle loss, and it aims to find new ways to help improve the lives of cancer patients by understanding the body's inflammation response.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF FLORIDA (nih funded) |
| Locations | 1 site (GAINESVILLE, UNITED STATES) |
| Trial ID | NIH-10898598 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding cancer cachexia, a condition that leads to severe muscle and weight loss in cancer patients. By examining the role of the complement system, which is involved in inflammation and tissue damage, the study aims to uncover the mechanisms that contribute to muscle wasting. Researchers will analyze muscle tissues from cancer patients and animal models to identify specific pathways and proteins that may be targeted for new treatments. The goal is to improve the quality of life and survival rates for those affected by this debilitating condition.
Who could benefit from this research
Good fit: Ideal candidates for this research are cancer patients experiencing cachexia, particularly those with pancreatic cancer.
Not a fit: Patients who are not currently experiencing significant muscle loss or cachexia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that prevent or reverse muscle loss in cancer patients, enhancing their overall health and treatment outcomes.
How similar studies have performed: Previous research has shown promising results in understanding the role of the complement system in muscle wasting, indicating that this approach may lead to significant advancements in treatment.
Where this research is happening
GAINESVILLE, UNITED STATES
- UNIVERSITY OF FLORIDA — GAINESVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: JUDGE, ANDREW ROBERT — UNIVERSITY OF FLORIDA
- Study coordinator: JUDGE, ANDREW ROBERT
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.