Investigating how the cleavage of a specific protein affects kidney disease
Polycystin-1 C terminal tail cleavage: Mechanisms and meaning
['FUNDING_R01'] · YALE UNIVERSITY · NIH-11050297
This study is looking at how a specific part of a protein related to kidney disease affects kidney health and cyst formation, with the hope of finding new ways to help people with autosomal dominant polycystic kidney disease (ADPKD).
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | YALE UNIVERSITY (nih funded) |
| Locations | 1 site (NEW HAVEN, UNITED STATES) |
| Trial ID | NIH-11050297 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the mechanisms behind the cleavage of the C-terminal tail of polycystin-1, a protein linked to autosomal dominant polycystic kidney disease (ADPKD). By studying how this cleavage affects cellular functions and contributes to the formation of kidney cysts, researchers aim to uncover new insights into the disease's progression. The approach involves using animal models to observe the effects of specific protein fragments on kidney health. This could lead to a better understanding of how to manage or treat ADPKD.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with autosomal dominant polycystic kidney disease.
Not a fit: Patients with other forms of kidney disease unrelated to ADPKD may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for managing or potentially reversing the effects of ADPKD.
How similar studies have performed: Previous research has shown promising results in understanding the role of polycystin proteins in kidney disease, suggesting that this approach could yield valuable insights.
Where this research is happening
NEW HAVEN, UNITED STATES
- YALE UNIVERSITY — NEW HAVEN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CAPLAN, MICHAEL J. — YALE UNIVERSITY
- Study coordinator: CAPLAN, MICHAEL J.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Adult Polycystic Kidney Disease, Autosomal Dominant Polycystic Kidney Disease