Investigating how the cleavage of a specific protein affects kidney disease
Official title: Polycystin-1 C terminal tail cleavage: Mechanisms and meaning
Funded at Yale University · NIH-11050297 · Data updated 2026-11-12
This study is looking at how a specific part of a protein related to kidney disease affects kidney health and cyst formation, with the hope of finding new ways to help people with autosomal dominant polycystic kidney disease (ADPKD).
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | January 1, 2025 |
| Project end | November 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $640,001 |
| NIH project number | 1R01DK139319-01A1 |
| Project ID | NIH-11050297 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with autosomal dominant polycystic kidney disease.
✕Less likely to help
Patients with other forms of kidney disease unrelated to ADPKD may not benefit from this research.
What this research studies
This research focuses on understanding the mechanisms behind the cleavage of the C-terminal tail of polycystin-1, a protein linked to autosomal dominant polycystic kidney disease (ADPKD). By studying how this cleavage affects cellular functions and contributes to the formation of kidney cysts, researchers aim to uncover new insights into the disease's progression. The approach involves using animal models to observe the effects of specific protein fragments on kidney health. This could lead to a better understanding of how to manage or treat ADPKD.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for managing or potentially reversing the effects of ADPKD.
How similar studies have gone: Previous research has shown promising results in understanding the role of polycystin proteins in kidney disease, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Caplan, Michael J. — Yale University
- Study coordinator: Caplan, Michael J.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.