Investigating how the choroid plexus senses fluid pressure in the brain
Official title: How does mechanosensation contribute to choroid plexus function in health and disease?
Funded at Scripps Research Institute, the · NIH-11105762 · Data updated 2026-11-12
This study is looking at a part of the brain called the choroid plexus, which makes the fluid that cushions your brain, to see if it can sense changes in that fluid's flow and pressure, and how this might help us find better ways to treat conditions like traumatic brain injury and hydrocephalus.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Scripps Research Institute, the NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | May 1, 2024 |
| Project end | April 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $78,040 |
| NIH project number | 5F32NS136266-02 |
| Project ID | NIH-11105762 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with neurological conditions that affect intracranial pressure, such as hydrocephalus, traumatic brain injury, or stroke.
✕Less likely to help
Patients with stable intracranial pressure and no neurological disorders may not benefit from this research.
What this research studies
This research focuses on the choroid plexus, a brain structure that produces cerebrospinal fluid (CSF) and regulates its volume. The study aims to understand whether the choroid plexus can detect changes in CSF flow and pressure, and how this sensing might affect CSF production. By exploring the mechanisms of mechanosensation in the choroid plexus, the research seeks to uncover how these processes relate to intracranial pressure (ICP) and its implications for various neurological conditions. The findings could lead to new therapeutic strategies for managing conditions associated with abnormal ICP, such as traumatic brain injury and hydrocephalus.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients suffering from conditions related to abnormal intracranial pressure.
How similar studies have gone: Previous research has shown promising results in understanding mechanosensation in other contexts, suggesting potential for success in this novel investigation.
Where this research is happening
-
Scripps Research Institute, the
La Jolla, United States Active
Researchers
- Principal investigator: Profaci, Caterina P — Scripps Research Institute, the
- Study coordinator: Profaci, Caterina P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.