Investigating how the cholera vaccine affects immune responses in humans
Human B cell responses to a live attenuated cholera vaccine
This study is exploring how a live cholera vaccine helps your immune system, especially looking at how it affects certain immune cells in adults, to find ways to make vaccines even better for protecting against cholera and similar infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-10434686 on NIH RePORTER |
What this research studies
This research focuses on understanding the immune responses generated by a live attenuated cholera vaccine, specifically looking at how it affects B cells in adults. The study aims to uncover the mechanisms behind the long-lasting immunity provided by natural cholera infections compared to current vaccines. By examining the behavior of memory B cells and their migration to the intestinal mucosa, researchers hope to identify factors that contribute to effective vaccination. This could lead to improved vaccine strategies for cholera and other mucosal pathogens.
Who could benefit from this research
Good fit: Ideal candidates for participation are adults aged 21 and older, particularly those living in regions affected by cholera.
Not a fit: Patients who are not adults or those who do not reside in cholera-endemic areas may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective cholera vaccines that provide longer-lasting immunity.
How similar studies have performed: Previous research has shown promising results with live attenuated vaccines in generating strong immune responses, suggesting potential success for this approach.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Wrammert, Jens Peter — Emory University
- Study coordinator: Wrammert, Jens Peter
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.