Investigating how the brain's drainage system works in humans
Quantitative Imaging of Brain Glymphatic Function in Humans
This study is looking at how the brain cleans itself and stays healthy, especially as we age or if we have certain brain conditions, and it involves some imaging tests to help us understand how this process works in people.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project ID | NIH-10805400 on NIH RePORTER |
What this research studies
This research focuses on understanding the brain's glymphatic system, which is responsible for clearing waste and maintaining brain health. By using advanced imaging techniques, the study aims to observe how this system functions in humans, particularly in relation to age and various neurological conditions. Patients may undergo imaging procedures to help researchers gather data on how the glymphatic system operates and its potential links to diseases like Alzheimer's. The findings could provide insights into the role of this system in brain health and disease.
Who could benefit from this research
Good fit: Ideal candidates for this research include adults aged 21 and older, particularly those experiencing cognitive decline or neurological symptoms.
Not a fit: Patients with acute neurological emergencies or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating neurodegenerative diseases by enhancing our understanding of brain waste clearance.
How similar studies have performed: While there is emerging evidence supporting the role of the glymphatic system in animal models, this research is among the first to apply these concepts directly to human subjects.
Where this research is happening
Nashville, United States
- Vanderbilt University Medical Center — Nashville, United States (Active)
Researchers
- Principal investigator: Donahue, Manus J — Vanderbilt University Medical Center
- Study coordinator: Donahue, Manus J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.