Investigating how the brain stabilizes function in health and disease
Official title: Homeostatic Stabilization of Neural Function in Health and Disease
Funded at University of California, San Francisco · NIH-10884059 · Data updated 2026-11-12
This study is looking at how the brain keeps itself balanced and stable, especially in conditions like autism and ALS, using fruit flies and mice to find new ways to help treat these disorders.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | December 15, 2024 |
| Project end | November 30, 2032 |
| Funding year | 2025 |
| Award (this year) | $1,174,913 |
| NIH project number | 1R35NS137247-01 |
| Project ID | NIH-10884059 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include adults diagnosed with autism spectrum disorder or amyotrophic lateral sclerosis.
✕Less likely to help
Patients with conditions unrelated to neurodevelopmental disorders or those under 21 years old may not benefit from this research.
What this research studies
This research explores the concept of homeostatic plasticity, which refers to the brain's ability to stabilize its function through compensatory processes. It aims to understand how these processes are linked to neurodevelopmental disorders such as autism and amyotrophic lateral sclerosis (ALS). The researchers will use advanced genetic techniques in fruit flies and mice to uncover the underlying mechanisms of homeostatic plasticity and its potential neuroprotective effects. By translating findings from fruit flies to mouse models, they hope to identify new therapeutic targets for treating these conditions.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve neural function and quality of life for individuals with neurodevelopmental disorders.
How similar studies have gone: Previous research has shown promising results in understanding homeostatic plasticity in animal models, suggesting potential for success in this novel approach.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Davis, Graeme W — University of California, San Francisco
- Study coordinator: Davis, Graeme W
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.