Investigating how the brain retrieves language and memory in Alzheimer's disease
Hippocampal-cortical networks underlying memory retrieval of linguistic knowledge
This study is looking at how language and memory work together in the brains of people with Alzheimer's and other memory issues, using special tools while they receive epilepsy treatment, to help improve our understanding and treatment of these conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-10665707 on NIH RePORTER |
What this research studies
This research explores the connection between language and memory in the brain, particularly in patients with Alzheimer's disease and other cognitive impairments. By using advanced techniques like high-density grid and depth electrodes, researchers will monitor brain activity in patients undergoing treatment for epilepsy. They will also employ a specially designed auditory naming task to study how language retrieval interacts with memory. This innovative approach aims to uncover the neural mechanisms involved in these processes, which could lead to better understanding and treatment of cognitive disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or other forms of dementia who are also undergoing treatment for refractory epilepsy.
Not a fit: Patients with mild cognitive impairment or those not diagnosed with Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved therapies for patients suffering from Alzheimer's disease and related cognitive impairments.
How similar studies have performed: Previous research has shown promising results in understanding the brain's language and memory integration, suggesting that this approach could yield valuable insights.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Kleen, Jonathan — University of California, San Francisco
- Study coordinator: Kleen, Jonathan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.