Investigating how the brain processes rewards in people with depression
Neuroimaging Studies of Reward Processing in Depression
['FUNDING_R37'] · MCLEAN HOSPITAL · NIH-11038034
This study is looking at how the brain works in people with Major Depressive Disorder and those who have recovered, focusing on why some people struggle to feel pleasure, and it’s for anyone dealing with depression or who has overcome it.
Quick facts
| Phase | ['FUNDING_R37'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MCLEAN HOSPITAL (nih funded) |
| Locations | 1 site (BELMONT, UNITED STATES) |
| Trial ID | NIH-11038034 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the brain mechanisms behind Major Depressive Disorder (MDD) and anhedonia, which is the inability to feel pleasure. By using advanced imaging techniques, including a special type of PET scan, the study aims to identify molecular and structural abnormalities in specific brain circuits involved in reward processing. Participants will include individuals currently experiencing depression as well as those who have recovered, allowing researchers to explore how these brain features change over time. The study also examines the role of inflammation in depression, providing a comprehensive view of the condition's biological underpinnings.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with Major Depressive Disorder, including those currently experiencing symptoms and those in remission.
Not a fit: Patients with depression who are currently on medication or those with other psychiatric disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for depression by identifying new biological targets for therapy.
How similar studies have performed: Previous research has shown promising results in understanding the neurobiological aspects of depression, making this approach both innovative and grounded in prior success.
Where this research is happening
BELMONT, UNITED STATES
- MCLEAN HOSPITAL — BELMONT, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PIZZAGALLI, DIEGO A — MCLEAN HOSPITAL
- Study coordinator: PIZZAGALLI, DIEGO A
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.