Investigating how the brain processes pain using targeted heating techniques
Psychophysical distillation of pure pain by nociceptive-specific heating
This study is looking at how our bodies process pain by using special tests and brain scans, and it’s designed for people with chronic pain to help understand their pain better and find new ways to measure it.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-10846260 on NIH RePORTER |
What this research studies
This research focuses on understanding pain processing mechanisms by using advanced techniques like quantitative sensory testing (QST) and functional magnetic resonance imaging (fMRI). The study aims to selectively stimulate nociceptors, which are responsible for sensing pain, by applying noxious heat to specific areas of skin that lack innocuous warmth receptors. This approach allows researchers to obtain unbiased measures of pain sensitivity and to observe pure brain activations related to pain. By developing computerized visual analogue scales, the research also aims to assess real-time changes in perceived pain, providing deeper insights into chronic pain conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals aged 65 and older who experience chronic pain conditions.
Not a fit: Patients who are younger than 65 or do not suffer from chronic pain may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment of chronic pain conditions, enhancing patient care.
How similar studies have performed: Previous research has shown promise in using targeted stimulation techniques to better understand pain mechanisms, suggesting potential for success in this novel approach.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Harper, Daniel Elliott — Emory University
- Study coordinator: Harper, Daniel Elliott
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.