Investigating how the brain controls body temperature regulation
Understanding how the thermogenic response is orchestrated in the central nervous system
This study is looking at how a part of the brain helps control body temperature and energy use, which could help us understand more about how our bodies stay warm and balanced.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-10864063 on NIH RePORTER |
What this research studies
This research explores the mechanisms by which the brain regulates body temperature, focusing on a specific area known as the dorsal raphe nucleus (DRN). The study aims to identify the neural circuits within the DRN that influence energy expenditure and thermogenesis, which is the process of heat production in organisms. Using advanced techniques like whole-brain activity mapping and chemogenetics, researchers will examine how these neurons respond to temperature changes and their role in thermoregulation. This work could enhance our understanding of how the brain manages body temperature and energy balance.
Who could benefit from this research
Good fit: Ideal candidates for this research would include individuals with metabolic disorders or conditions affecting body temperature regulation.
Not a fit: Patients with stable body temperature regulation and no metabolic issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into treatments for conditions related to temperature regulation and metabolic disorders.
How similar studies have performed: Previous research has shown promising results in understanding brain mechanisms related to thermoregulation, indicating that this approach has potential for success.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Schneeberger, Marc — Yale University
- Study coordinator: Schneeberger, Marc
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.