Investigating how the brain clears toxic proteins in Alzheimer's disease
Official title: Differential clearance of pyroglutamate abeta through arachnoid and meningeal lymphatics in Alzheimer Disease
Funded at Rowan University School/osteopathic Med · NIH-10631074 · Data updated 2026-11-12
This study is looking at how a special system around the brain helps remove harmful proteins that build up in people with Alzheimer's disease, with the hope of finding new ways to keep the brain healthier and slow down the disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rowan University School/osteopathic Med NIH-funded |
| Lab location | 1 site (Stratford, United States) |
| Project start | September 1, 2019 |
| Project end | June 30, 2025 |
| Funding year | 2023 |
| Award (this year) | $376,762 |
| NIH project number | 5R01AG064226-06 |
| Project ID | NIH-10631074 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those exhibiting early signs of cognitive decline.
✕Less likely to help
Patients with other forms of dementia unrelated to amyloid beta accumulation may not benefit from this research.
What this research studies
This research explores the mechanisms behind the impaired clearance of toxic proteins, specifically amyloid beta (Aβ), in the brains of individuals with Alzheimer's disease. It focuses on understanding the role of the meningeal lymphatic system, a newly discovered network of drainage vessels surrounding the brain, in the removal of these harmful substances. By examining how these lymphatic pathways function, the research aims to identify new therapeutic strategies to improve brain health and potentially prevent or slow the progression of Alzheimer's disease.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance the brain's ability to clear toxic proteins, potentially slowing the progression of Alzheimer's disease.
How similar studies have gone: While the role of lymphatic systems in brain health is a relatively new area of investigation, preliminary findings suggest that targeting these pathways could be promising, though this specific approach remains largely untested.
Where this research is happening
-
Rowan University School/osteopathic Med
Stratford, United States Active
Researchers
- Principal investigator: Janson, Christopher G. — Rowan University School/osteopathic Med
- Study coordinator: Janson, Christopher G.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.