Investigating how the body responds to Shigella infections
Host factors in shigellosis
['FUNDING_R01'] · UNIVERSITY OF VIRGINIA · NIH-10991660
This study is looking at how the Shigella bacteria cause illness in young rabbits to help us better understand how these infections affect people, especially when it comes to the immune system's response.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF VIRGINIA (nih funded) |
| Locations | 1 site (CHARLOTTESVILLE, UNITED STATES) |
| Trial ID | NIH-10991660 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how the body reacts to infections caused by the Shigella bacteria, which leads to bacillary dysentery. Using infant rabbits as a model, the researchers aim to explore how the bacteria invade the colon and the role of immune cells in the disease process. By studying these interactions, the research seeks to clarify controversial aspects of Shigella infections and improve our understanding of the disease's impact on human health.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals, particularly children and adults, who are at risk of or have experienced Shigella infections.
Not a fit: Patients who are not affected by Shigella infections or do not have a history of dysentery may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better treatments and prevention strategies for Shigella infections, potentially reducing the incidence of dysentery.
How similar studies have performed: Previous research has shown success in using animal models to study bacterial infections, but this specific approach using infant rabbits for Shigella is relatively novel.
Where this research is happening
CHARLOTTESVILLE, UNITED STATES
- UNIVERSITY OF VIRGINIA — CHARLOTTESVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: AGAISSE, HERVE F — UNIVERSITY OF VIRGINIA
- Study coordinator: AGAISSE, HERVE F
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: acute infection