Investigating how the body responds to sepsis and its effects on metabolism
Official title: Yap1/TAZ and CD14 in the Catabolic Response to Sepsis
Funded at Portland VA Medical Center · NIH-11095736 · Data updated 2026-11-12
This study is looking at how the body reacts to severe infections like sepsis, especially how it breaks down muscle and fat to help heal, and it hopes to find new ways to improve recovery for patients dealing with this condition.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Portland VA Medical Center NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project start | April 1, 2024 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| NIH project number | 5I01BX006433-02 |
| Project ID | NIH-11095736 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients experiencing sepsis or severe infections that impact their metabolism and recovery.
✕Less likely to help
Patients with stable chronic conditions unrelated to sepsis or metabolic responses may not benefit from this research.
What this research studies
This research focuses on understanding the body's catabolic response to sepsis, which is a severe infection that can lead to organ damage. It examines how the innate immune system activates and breaks down muscle and fat to provide essential nutrients for recovery. By studying the molecular mechanisms involved, particularly the roles of specific proteins like Yap1 and TAZ, the research aims to uncover potential treatments that could improve patient outcomes during sepsis. The approach includes analyzing metabolic changes and the production of proteins that help in tissue repair.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that enhance recovery from sepsis and improve muscle mass and strength in affected patients.
How similar studies have gone: Previous research has shown promising results in understanding metabolic responses to sepsis, but this specific approach focusing on Yap1/TAZ is relatively novel.
Where this research is happening
-
Portland VA Medical Center
Portland, United States Active
Researchers
- Principal investigator: Koniaris, Leonidas G. — Portland VA Medical Center
- Study coordinator: Koniaris, Leonidas G.
Related research
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This research tests whether blocking MMP3 can protect the heart and improve survival during sepsis in adults.
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Sepsis patient care guided by Ugandan-wide immune profiling
A large NIH-funded study will map how the immune system behaves during sepsis in people in Uganda to improve personalized care for sepsis patients.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.