Investigating how the body responds to chronic hepatitis B virus infection using a mouse model.
Human mechanisms of virus persistence in an AAV-based mouse model of chronic HBV infection
This study is looking at how the immune system responds to chronic hepatitis B infection in a special mouse model that acts like humans, to help find better treatments for people struggling to fight off the virus.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albany Medical College NIH-funded |
| Lab location | 1 site (Albany, United States) |
| Project ID | NIH-10827923 on NIH RePORTER |
What this research studies
This research focuses on understanding the immune response to chronic hepatitis B virus (HBV) infection, which is often ineffective. By using a new mouse model that mimics human HBV infection, researchers aim to uncover the mechanisms behind T cell dysfunction and immune tolerance to the virus. The study will explore how liver-resident immune cells and various signaling pathways contribute to the body's inability to control HBV. Insights gained from this research could lead to the development of new immunotherapies for chronic HBV.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with chronic hepatitis B virus infection who have not responded well to existing treatments.
Not a fit: Patients with acute hepatitis B or those who have cleared the virus may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that effectively eliminate chronic hepatitis B virus from the body.
How similar studies have performed: Previous research has shown promise in using animal models to study viral infections, suggesting that this approach could yield valuable insights.
Where this research is happening
Albany, United States
- Albany Medical College — Albany, United States (Active)
Researchers
- Principal investigator: Robek, Michael — Albany Medical College
- Study coordinator: Robek, Michael
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.