Investigating how the blood-brain barrier affects brain health in CADASIL patients
BBB Permeability Imaging in CADASIL
This study is looking at how the blood-brain barrier works in people with CADASIL, a genetic condition that can cause strokes and memory problems, to see how changes in this barrier might affect brain health over time.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Southern California NIH-funded |
| Lab location | 1 site (Los Angeles, UNITED STATES) |
| Project ID | NIH-10772973 on NIH RePORTER |
What this research studies
This research aims to explore the role of the blood-brain barrier (BBB) in cerebral small vessel disease (SVD), particularly in patients with CADASIL, a genetic condition that can lead to strokes and dementia. By using advanced imaging techniques, the study will assess how the BBB's permeability changes over time and how these changes relate to cognitive decline and brain damage. The research will involve a cohort of CADASIL patients in China, utilizing innovative MRI methods to gather data on brain health and disease progression.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with CADASIL, particularly those with NOTCH3 mutations.
Not a fit: Patients without CADASIL or those with other unrelated neurological conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier detection and better management of cerebral small vessel disease, potentially improving outcomes for patients.
How similar studies have performed: Previous research has shown promise in using imaging techniques to study the blood-brain barrier, suggesting that this approach could yield valuable insights.
Where this research is happening
Los Angeles, UNITED STATES
- University of Southern California — Los Angeles, United States (Active)
Researchers
- Principal investigator: Wang, Danny Jj — University of Southern California
- Study coordinator: Wang, Danny Jj
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.