Investigating how the BLM protein helps prevent DNA damage
Causes and consequences of Blm-dependent DNA replication challenges
['FUNDING_OTHER'] · LEWIS-CLARK STATE COLLEGE · NIH-10894804
This study is looking at how a protein called BLM helps keep our DNA safe from damage, especially in people with Bloom Syndrome, by using fruit flies to see what happens when this protein is missing during early development.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | LEWIS-CLARK STATE COLLEGE (nih funded) |
| Locations | 1 site (LEWISTON, UNITED STATES) |
| Trial ID | NIH-10894804 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of the BLM protein in protecting DNA from damage caused by repetitive sequences. Using fruit flies as a model organism, the study aims to explore how the absence of BLM affects DNA replication and the long-term consequences of this deficiency during early development. By identifying specific repetitive sequences that challenge DNA replication, the research seeks to shed light on the mechanisms behind Bloom Syndrome, a condition linked to developmental issues and cancer susceptibility.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Bloom Syndrome or those with a family history of the condition.
Not a fit: Patients without Bloom Syndrome or related genetic disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and potential treatments for Bloom Syndrome and related conditions.
How similar studies have performed: While the specific approach using Drosophila is novel, previous research has shown that understanding DNA repair mechanisms can lead to significant advancements in treating genetic disorders.
Where this research is happening
LEWISTON, UNITED STATES
- LEWIS-CLARK STATE COLLEGE — LEWISTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: STOFFREGEN, ERIC PAUL — LEWIS-CLARK STATE COLLEGE
- Study coordinator: STOFFREGEN, ERIC PAUL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Bloom Syndrome, Bloom syndrome protein, Bloom-Torre-Machacek Syndrome, Cancers