Investigating how the bladder's surrounding tissue influences cancer development and progression
The stromal microenvironment as a co-organizer of bladder carcinogenesis and progression
This study is looking at how the area around bladder tumors affects the growth of non-muscle invasive bladder cancer, and it's for patients who want to help us learn more about their condition by providing tissue samples and information that could lead to better treatments.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Methodist Hospital Research Institute NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-10708917 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of the stromal microenvironment in bladder cancer, particularly non-muscle invasive bladder cancers (NMIBCs). It involves collecting tissue samples and clinical data from patients to create a detailed spatial map of the tumor environment. The study employs advanced techniques like spatial transcriptomics and bioinformatics to analyze how these surrounding tissues contribute to cancer progression. By centralizing tissue collection and data analysis, the research aims to enhance our understanding of bladder cancer and improve patient outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with non-muscle invasive bladder cancer.
Not a fit: Patients with muscle-invasive bladder cancer or those without a diagnosis of bladder cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better diagnostic tools and treatment strategies for bladder cancer patients.
How similar studies have performed: Previous research has shown promise in understanding tumor microenvironments in other cancers, suggesting potential for success in this novel approach.
Where this research is happening
Houston, United States
- Methodist Hospital Research Institute — Houston, United States (Active)
Researchers
- Principal investigator: Lewis, Michael Stanley — Methodist Hospital Research Institute
- Study coordinator: Lewis, Michael Stanley
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.