Investigating how the APOE gene affects brain cell function in Alzheimer's disease.
Official title: The effects of APOE genotype in homeostatic microglial function in preclinical APOE mouse model
Funded at Georgetown University · NIH-10922870 · Data updated 2026-11-12
This study is looking at how a specific gene called APOE4 affects brain cells that help keep our brains healthy, using a special mouse model to see how these cells react to damage and inflammation, which could help us find new ways to treat Alzheimer's disease before it starts.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Georgetown University NIH-funded |
| Lab location | 1 site (Washington, United States) |
| Project start | September 6, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $37,274 |
| NIH project number | 5F99NS134164-02 |
| Project ID | NIH-10922870 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with a family history of Alzheimer's disease or those who carry the APOE4 allele.
✕Less likely to help
Patients without any genetic predisposition to Alzheimer's disease or those who do not carry the APOE4 allele may not benefit from this research.
What this research studies
This research focuses on understanding the role of the APOE gene, particularly the APOE4 variant, in the function of microglial cells, which are crucial for maintaining brain health. Using a special mouse model that mimics human genetics, the researchers will explore how APOE4 influences microglial behavior, especially in response to damage and inflammation. The study aims to uncover the molecular mechanisms that lead to changes in microglial function before the onset of Alzheimer's disease, potentially revealing new targets for treatment.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating Alzheimer's disease by targeting the underlying mechanisms affected by the APOE4 genotype.
How similar studies have gone: Previous research has shown promising results in understanding the role of APOE in Alzheimer's disease, indicating that this approach has potential for significant findings.
Where this research is happening
-
Georgetown University
Washington, United States Active
Researchers
- Principal investigator: Sepulveda, Jordy F — Georgetown University
- Study coordinator: Sepulveda, Jordy F
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.