Investigating how the anti-aging protein Klotho affects cognitive health in Parkinson's disease.
Enhancing Cognitive Resilience In Parkinson's Disease: Role Of Antiaging Protein Klotho
['FUNDING_OTHER'] · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · NIH-10930695
This study is looking at how a special protein called Klotho, which helps with aging, can boost brain health for people with Parkinson's disease, especially when combined with exercise, to see if it can help prevent memory and thinking problems.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN FRANCISCO (nih funded) |
| Locations | 1 site (SAN FRANCISCO, UNITED STATES) |
| Trial ID | NIH-10930695 on ClinicalTrials.gov |
What this research studies
This research explores the role of Klotho, an anti-aging protein, in enhancing cognitive resilience for individuals with Parkinson's disease (PD). The study aims to understand how physical exercise influences Klotho levels and whether these changes can help protect against cognitive decline associated with PD. By identifying biomarkers that respond to exercise, the research seeks to uncover mechanisms that could improve cognitive outcomes for patients. The principal investigator, Dr. Nijee Luthra, is focused on developing strategies to counteract cognitive impairment in the growing PD population.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults diagnosed with Parkinson's disease who are experiencing cognitive decline.
Not a fit: Patients with Parkinson's disease who are not experiencing cognitive issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new interventions that improve cognitive function and quality of life for patients with Parkinson's disease.
How similar studies have performed: Previous research has shown that exercise can enhance Klotho levels and cognitive function in healthy adults, suggesting potential for success in this novel approach for PD.
Where this research is happening
SAN FRANCISCO, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN FRANCISCO — SAN FRANCISCO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LUTHRA, NIJEE — UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- Study coordinator: LUTHRA, NIJEE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.