Investigating how THC affects brain development in ferrets.
A Novel Animal Model to Investigate the Effects of Delta-9 - Tetrahydrocannabinol in the Primary Visual Cortex of Ferrets.
['FUNDING_FELLOWSHIP'] · UNIVERSITY OF MARYLAND BALTIMORE · NIH-10823504
This study looks at how exposure to THC, a key ingredient in cannabis, affects brain development in ferrets during a crucial growth period, helping us understand the possible risks of using cannabis while pregnant.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MARYLAND BALTIMORE (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-10823504 on ClinicalTrials.gov |
What this research studies
This research explores the impact of Delta-9-Tetrahydrocannabinol (THC), a psychoactive component of cannabis, on brain development during the critical third trimester equivalent in ferrets. The study focuses on how THC exposure influences the density and function of cannabinoid type-1 receptors (CB1Rs) in the primary visual cortex, which is crucial for understanding synaptic plasticity. By using an animal model, the research aims to uncover the long-term effects of prenatal THC exposure on brain development and function, providing insights into potential risks associated with cannabis use during pregnancy.
Who could benefit from this research
Good fit: Ideal candidates for this research are pregnant individuals who use cannabis and are concerned about its effects on fetal development.
Not a fit: Patients who do not use cannabis or are not pregnant may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide critical insights into the risks of cannabis use during pregnancy and its effects on fetal brain development.
How similar studies have performed: While there is limited research specifically on THC's effects during pregnancy, studies on cannabinoids and brain development suggest potential risks, indicating that this area is both relevant and necessary for further exploration.
Where this research is happening
BALTIMORE, UNITED STATES
- UNIVERSITY OF MARYLAND BALTIMORE — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PRUITT, MOLLY ELIZABETH — UNIVERSITY OF MARYLAND BALTIMORE
- Study coordinator: PRUITT, MOLLY ELIZABETH
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Angelman Syndrome