Investigating how TGFb affects the thoracic aorta and related diseases
Official title: TGFb-Dependent Cell-Matrix Interactions in Thoracic Aortopathy
Funded at Yale University · NIH-11015432 · Data updated 2026-11-12
This study is looking at how a protein called TGFβ affects heart and blood vessel problems, like aneurysms and dissections, especially in people with certain genetic conditions, to find new ways to help improve their health.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | January 15, 2025 |
| Project end | November 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $358,300 |
| NIH project number | 1P01HL169168-01A1 |
| Project ID | NIH-11015432 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with thoracic aortic diseases, particularly those with genetic conditions like Loeys-Dietz syndrome.
✕Less likely to help
Patients without thoracic aortic diseases or those not affected by genetic predispositions related to TGFβ signaling may not benefit from this research.
What this research studies
This research focuses on understanding the role of transforming growth factor-beta (TGFβ) in thoracic aortic diseases, which include conditions like aneurysms and dissections. The study aims to clarify the mechanisms by which TGFβ signaling may contribute to these diseases, particularly in patients with genetic predispositions such as Loeys-Dietz syndrome. By examining both increased and decreased TGFβ signaling in the aorta, the researchers hope to identify new therapeutic strategies to improve patient outcomes. The approach includes using animal models to observe the effects of TGFβ disruption on aortic health.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that better manage or prevent thoracic aortic diseases.
How similar studies have gone: Previous research has shown promising results in understanding TGFβ signaling in aortic diseases, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Tellides, George — Yale University
- Study coordinator: Tellides, George
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.