Investigating how TGF-Beta affects airway smooth muscle in cystic fibrosis
TGF-Beta Regulates CFTR-Mediated Airway Smooth Muscle Dysfunction
This study is looking at how a protein called TGF-Beta affects lung problems in people with cystic fibrosis, with the hope of finding new ways to help improve their breathing.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project ID | NIH-11005012 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of TGF-Beta, a protein that influences inflammation and tissue repair, in the airway smooth muscle dysfunction seen in cystic fibrosis (CF). By using animal models and human cell cultures, the study aims to explore how TGF-Beta contributes to airway hyperresponsiveness and obstruction in CF patients. The research will specifically look at the interactions between CFTR, a protein affected by CF mutations, and TGF-Beta signaling pathways. This could lead to new insights into potential therapies targeting these mechanisms to improve lung function in CF patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with cystic fibrosis, particularly those experiencing airway obstruction and hyperresponsiveness.
Not a fit: Patients without cystic fibrosis or those whose condition is not related to airway smooth muscle dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that specifically address airway smooth muscle dysfunction in cystic fibrosis, potentially improving lung function and quality of life for patients.
How similar studies have performed: While the specific approach of targeting TGF-Beta in cystic fibrosis is novel, similar studies have shown promise in understanding the role of inflammatory mediators in other respiratory conditions.
Where this research is happening
Cincinnati, United States
- Cincinnati Childrens Hosp Med Ctr — Cincinnati, United States (Active)
Researchers
- Principal investigator: Kramer, Elizabeth L — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Kramer, Elizabeth L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.