Investigating how TFAP4 affects lysosome function and tau-related brain diseases
Evaluation of TFAP4 regulation of lysosome biogenesis and modulation of tau pathology
This study is looking at how a protein called TFAP4 can help improve the way our cells clean up harmful proteins linked to Alzheimer's disease, with the hope of finding new ways to protect brain cells and help people with neurodegenerative conditions.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-11066701 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of TFAP4 in regulating lysosome biogenesis, which is crucial for clearing toxic proteins associated with Alzheimer's disease and related tauopathies. By enhancing the autophagy-lysosome pathway, the study aims to find new therapeutic strategies to prevent or reduce neuron loss caused by toxic tau accumulation. The approach includes in vitro experiments to assess how manipulating TFAP4 levels can influence lysosomal function and potentially improve outcomes for patients with neurodegenerative diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or related tauopathies.
Not a fit: Patients with non-neurodegenerative conditions or those without tau pathology may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that slow down or prevent the progression of Alzheimer's disease and related conditions.
How similar studies have performed: Previous research has shown promise in targeting lysosomal function to treat neurodegenerative diseases, indicating that this approach may be viable.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Owens, Ashley — Yale University
- Study coordinator: Owens, Ashley
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.