Investigating how TET2 regulates blood stem cells through RNA modifications
Official title: Critical roles of RNA m5C-MBD6-H2AK119ub deubiquitylation axis in TET2-mediated HSC regulation
Funded at University of Texas Hlth Science Center · NIH-10937700 · Data updated 2026-11-12
This study is looking at how a protein called TET2 helps control blood stem cells, which are important for making blood cells, and it hopes to find new ways to improve treatments for blood disorders like myeloid cancers.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Science Center NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $717,415 |
| NIH project number | 1R01HL174477-01 |
| Project ID | NIH-10937700 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include adults with myeloid malignancies or those experiencing clonal hematopoiesis.
✕Less likely to help
Patients with non-hematological conditions or those outside the age range of 21+ years may not benefit from this research.
What this research studies
This research focuses on understanding the role of the TET2 protein in regulating hematopoietic stem and progenitor cells (HSPCs), which are crucial for blood cell formation. The study examines how TET2 influences RNA modifications and chromatin states, potentially affecting the self-renewal and differentiation of these stem cells. By exploring the interactions between TET2, RNA, and specific proteins, the research aims to uncover new mechanisms that could lead to better treatments for blood-related disorders. Patients may benefit from insights gained about how to manage conditions like myeloid malignancies.
Why it matters
Potential benefit: If successful, this research could lead to improved therapies for patients with blood cancers and other hematological conditions.
How similar studies have gone: Previous research has shown promising results in understanding RNA modifications and their impact on cell regulation, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Texas Hlth Science Center
San Antonio, United States Active
Researchers
- Principal investigator: Xu, Mingjiang — University of Texas Hlth Science Center
- Study coordinator: Xu, Mingjiang
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.