Investigating how TET2 affects uterine function and fertility
Official title: TET2 as a novel epigenetic regulator for uterine function and fertility
Funded at North Carolina State University Raleigh · NIH-10725828 · Data updated 2026-11-12
This study is looking at how a protein called TET2 affects the uterus and fertility by working with hormones to create a healthy environment for embryos to implant, which could help us understand and treat issues like infertility, endometriosis, and uterine cancers.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | North Carolina State University Raleigh NIH-funded |
| Lab location | 1 site (Raleigh, United States) |
| Project start | August 8, 2023 |
| Project end | July 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $152,000 |
| NIH project number | 1R03HD112581-01 |
| Project ID | NIH-10725828 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include women experiencing infertility or subfertility, particularly those with conditions like endometriosis.
✕Less likely to help
Patients who are not experiencing fertility issues or have already undergone successful fertility treatments may not benefit from this research.
What this research studies
This research focuses on understanding the role of TET2, an epigenetic regulator, in uterine function and fertility. It examines how TET2 interacts with ovarian hormones like estrogen and progesterone to influence the endometrial environment necessary for embryo implantation. By studying both human and mouse models, the research aims to uncover the mechanisms behind infertility and subfertility related to endometrial adaptation. The findings could lead to new insights into the treatment of conditions like endometriosis and uterine cancers.
Why it matters
Potential benefit: If successful, this research could lead to improved fertility treatments and better management of uterine-related health issues.
How similar studies have gone: Other research has shown promising results in understanding the role of epigenetic factors in fertility, suggesting that this approach could yield valuable insights.
Where this research is happening
-
North Carolina State University Raleigh
Raleigh, United States Active
Researchers
- Principal investigator: Wang, Xiaoqiu — North Carolina State University Raleigh
- Study coordinator: Wang, Xiaoqiu
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.