Investigating how temperature affects immune responses in mice
Official title: Examining the impact of laboratory housing temperature on murine CD28 and the response to anti-PD-1
Funded at Roswell Park Cancer Institute Corp · NIH-10918087 · Data updated 2026-11-12
This study is looking at how different temperatures in a lab affect the immune system of mice, especially a marker called CD28, to see how these changes might help us understand and improve cancer treatments for people.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Roswell Park Cancer Institute Corp NIH-funded |
| Lab location | 1 site (Buffalo, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $36,792 |
| NIH project number | 5F31CA288029-02 |
| Project ID | NIH-10918087 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for benefiting from this research are individuals undergoing cancer treatment or those involved in clinical trials for new cancer therapies.
✕Less likely to help
Patients with conditions unrelated to cancer or those not participating in clinical trials may not receive direct benefits from this research.
What this research studies
This research examines how different laboratory housing temperatures impact the immune response of mice, particularly focusing on a specific immune marker known as CD28. By manipulating the temperature in which these animals are housed, the study aims to understand how these conditions influence the effectiveness of cancer treatments, such as anti-PD-1 therapies. The approach involves monitoring physiological changes in the mice and correlating these with their immune responses to better predict outcomes in human cancer therapies. This could lead to improved preclinical models that better reflect human responses to treatment.
Why it matters
Potential benefit: If successful, this research could enhance the reliability of preclinical models, leading to more effective cancer treatments for patients.
How similar studies have gone: While the specific focus on temperature's impact on CD28 in murine models is novel, similar studies have shown that environmental factors can significantly influence the outcomes of preclinical research.
Where this research is happening
-
Roswell Park Cancer Institute Corp
Buffalo, United States Active
Researchers
- Principal investigator: James, Caitlin M — Roswell Park Cancer Institute Corp
- Study coordinator: James, Caitlin M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.