Investigating how temperature affects enzyme reactions and their efficiency
Official title: Temperature Dependence of Hydride Kinetic Isotope Effects in Solution to Test the Proposed Role of Protein Dynamics in Enzyme Catalysis
Funded at Southern Illinois Univ at Edwardsville · NIH-10580264 · Data updated 2026-11-12
This study looks at how temperature affects the way proteins work in enzymes, which could help scientists create better drugs for patients by understanding how these enzymes speed up chemical reactions in the body.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Southern Illinois Univ at Edwardsville NIH-funded |
| Lab location | 1 site (Edwardsville, United States) |
| Project start | September 15, 2022 |
| Project end | August 31, 2025 |
| Funding year | 2022 |
| Award (this year) | $433,500 |
| NIH project number | 1R15GM148951-01 |
| Project ID | NIH-10580264 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for benefiting from this research include individuals requiring innovative drug therapies or those involved in clinical trials for new medications.
✕Less likely to help
Patients with conditions that do not involve enzyme-related drug metabolism may not receive direct benefits from this research.
What this research studies
This research explores the relationship between protein dynamics and enzyme catalysis, focusing on how temperature influences the kinetic isotope effects (KIEs) in enzymatic reactions. By examining hydrogen tunneling reactions, the study aims to understand how variations in donor-acceptor distances impact enzyme efficiency. The methodology involves analyzing how temperature changes affect these distances and the resulting reaction rates, which could lead to insights into designing better drugs and biocatalysts. Patients may benefit from advancements in drug development that arise from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of more efficient drugs and biocatalysts, improving treatment options for patients.
How similar studies have gone: Previous research has shown that understanding kinetic isotope effects can lead to significant advancements in enzyme catalysis, indicating potential success for this approach.
Where this research is happening
-
Southern Illinois Univ at Edwardsville
Edwardsville, United States Active
Researchers
- Principal investigator: Lu, Yun — Southern Illinois Univ at Edwardsville
- Study coordinator: Lu, Yun
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.