Investigating how telomere dysfunction may cause chronic lung transplant failure
Telomere Dysfunction as a cause of Chronic Lung Allograft Dysfunction
This study is looking at how problems with telomeres, which are protective parts of our DNA, might affect the health of lung transplants, and it’s for lung transplant patients who can help by sharing their blood samples and health information.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-11082902 on NIH RePORTER |
What this research studies
This research explores the role of telomere dysfunction in chronic lung allograft dysfunction (CLAD), a significant complication following lung transplantation. By examining the genetic variants of telomeres in lung transplant recipients and their donors, the study aims to understand how telomere health impacts lung transplant survival. The research utilizes a combination of patient data analysis and experimental models to uncover the mechanisms behind telomere dysfunction and its potential link to the failure of lung transplants. Patients may be involved in providing blood samples and clinical data to support these investigations.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who have undergone lung transplantation or are on the waiting list for a lung transplant.
Not a fit: Patients with lung conditions unrelated to transplantation or those who have not received a lung transplant may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for predicting and preventing chronic lung transplant failure, enhancing patient survival rates.
How similar studies have performed: Previous research has indicated that telomere dysfunction is linked to various diseases, suggesting that this approach may yield valuable insights into lung transplant outcomes.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Greenland, John — University of California, San Francisco
- Study coordinator: Greenland, John
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.