Investigating how telomere dysfunction may cause chronic lung transplant failure
Telomere Dysfunction as a cause of Chronic Lung Allograft Dysfunction
This study is looking at how changes in the protective ends of chromosomes, called telomeres, might affect the health of lung transplant patients and whether these changes can help predict how well they will do after surgery, and we’d love to have patients share their blood samples and health information to help us learn more.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-10869891 on NIH RePORTER |
What this research studies
This research explores the role of telomere dysfunction in chronic lung allograft dysfunction (CLAD), a significant complication following lung transplantation. The study aims to understand whether telomere shortening in lung transplant donors can predict survival outcomes in recipients. By examining the genetic variants associated with telomere dysfunction and their impact on airway progenitor cells, the research seeks to uncover the underlying mechanisms that lead to CLAD. Patients may be involved in providing blood samples and clinical data to help establish these associations.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who have undergone lung transplantation or are on the waiting list for a lung transplant.
Not a fit: Patients with lung diseases not requiring transplantation or those who have not undergone lung transplant procedures may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for predicting and managing chronic lung transplant dysfunction, potentially extending the survival of lung transplant recipients.
How similar studies have performed: Previous studies have indicated that telomere dysfunction is linked to various diseases, suggesting that this approach may yield valuable insights, although the specific application to CLAD is still being explored.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Greenland, John — University of California, San Francisco
- Study coordinator: Greenland, John
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.