Investigating how telomere dysfunction in lung cells contributes to lung disease
Lung Remodeling Mediated by Telomere Dysfunction in Alveolar Type II Cells
This study is looking at how problems with tiny protective caps on our DNA, called telomeres, in certain lung cells might play a role in the scarring of lungs seen in idiopathic pulmonary fibrosis (IPF), and it aims to find new ways to help treat this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-11012302 on NIH RePORTER |
What this research studies
This research focuses on idiopathic pulmonary fibrosis (IPF), a serious lung condition characterized by progressive scarring of lung tissue. The study aims to understand how dysfunctional telomeres in alveolar type II cells contribute to the disease process. By using a novel mouse model that isolates telomere dysfunction, researchers will explore the cellular and molecular changes that occur in the lungs. This approach may reveal critical insights into the mechanisms driving lung fibrosis and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults diagnosed with idiopathic pulmonary fibrosis or those at risk for developing this condition.
Not a fit: Patients with lung diseases unrelated to telomere dysfunction or those without a diagnosis of idiopathic pulmonary fibrosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for patients suffering from idiopathic pulmonary fibrosis.
How similar studies have performed: Previous research has shown promising results in understanding lung fibrosis mechanisms, but this specific approach using telomere dysfunction is relatively novel.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Wolters, Paul J — University of California, San Francisco
- Study coordinator: Wolters, Paul J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.