Investigating how telomere damage contributes to liver cancer
Telomere dysfunction and telomerase reactivation in the etiology and progression of liver cancer
['FUNDING_R01'] · WASHINGTON UNIVERSITY · NIH-10982521
This study is looking at how problems with certain parts of our DNA, called telomeres, might lead to liver cancer, and it's for anyone interested in understanding more about liver cancer and possible new treatments.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WASHINGTON UNIVERSITY (nih funded) |
| Locations | 1 site (SAINT LOUIS, UNITED STATES) |
| Trial ID | NIH-10982521 on ClinicalTrials.gov |
What this research studies
This research explores the role of telomere dysfunction and telomerase reactivation in the development and progression of liver cancer. By utilizing human pluripotent stem cells, the study aims to uncover the molecular mechanisms that lead to liver fibrosis and hepatocellular carcinoma (HCC) due to DNA damage from shortened telomeres. The researchers will analyze how mutations in telomerase affect liver cell function and contribute to cancer development, providing insights into potential therapeutic targets. Patients may benefit from a better understanding of liver cancer etiology and new treatment strategies derived from these findings.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with liver fibrosis or those at high risk for developing hepatocellular carcinoma.
Not a fit: Patients with liver cancer unrelated to telomere dysfunction or those without liver disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention and treatment strategies for liver cancer.
How similar studies have performed: Previous research has shown promising results in understanding telomere dysfunction in other cancers, suggesting potential for success in this area as well.
Where this research is happening
SAINT LOUIS, UNITED STATES
- WASHINGTON UNIVERSITY — SAINT LOUIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BATISTA, LUIS FRANCISCO ZIRNBERGER — WASHINGTON UNIVERSITY
- Study coordinator: BATISTA, LUIS FRANCISCO ZIRNBERGER
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: cell injury