Investigating how TDP-43 protein changes contribute to neurodegenerative diseases
TDP-43 acetylation, phase separation, aggregation, and clearance by antibody-mediated degradation
This study is looking at how a protein called TDP-43 changes as we age and how those changes might contribute to diseases like Alzheimer's and frontotemporal dementia, with the hope of finding new ways to help people with these conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-11065480 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of TDP-43 protein in various age-related neurodegenerative diseases, such as Alzheimer's and frontotemporal dementia. It explores how TDP-43 undergoes changes like acetylation, which affects its behavior and contributes to neuronal death. By studying the mechanisms behind TDP-43 aggregation and clearance, the research aims to identify potential therapeutic targets that could help mitigate these diseases. Patients may benefit from insights that could lead to new treatments or interventions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with age-related neurodegenerative conditions such as Alzheimer's disease or frontotemporal dementia.
Not a fit: Patients with neurodegenerative diseases not associated with TDP-43 aggregation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating age-related neurodegenerative diseases.
How similar studies have performed: Other research has shown promising results in targeting protein aggregation in neurodegenerative diseases, suggesting that this approach may be viable.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Cleveland, Don W — University of California, San Diego
- Study coordinator: Cleveland, Don W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.