Investigating how TDP-43 protein behaves under stress in Alzheimer's-related diseases
Official title: Poly(ADP-ribose)-dependent TDP-43 pathology in oxidative stress (R21)
Funded at University of Alabama at Birmingham · NIH-10753095 · Data updated 2026-11-12
This study is looking at a protein called TDP-43 that is connected to Alzheimer's and frontotemporal dementia, to see how it behaves under stress and how that might help us find new ways to treat these conditions for patients like you.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $408,375 |
| NIH project number | 1R21AG084284-01 |
| Project ID | NIH-10753095 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with Alzheimer's disease or frontotemporal dementia.
✕Less likely to help
Patients with other forms of dementia not related to TDP-43 pathology may not benefit from this research.
What this research studies
This research focuses on understanding the behavior of a protein called TDP-43, which is linked to Alzheimer's disease and frontotemporal dementia. The study aims to uncover how TDP-43 is exported from the nucleus of cells during stress conditions, which may contribute to the progression of these diseases. By examining the interactions between TDP-43 and other molecules, the researchers hope to identify potential therapeutic targets that could prevent or reduce TDP-43 accumulation in the brain. Patients may benefit from insights gained into the underlying mechanisms of their conditions.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that slow down or prevent the progression of Alzheimer's disease and related dementias.
How similar studies have gone: Previous studies have shown that targeting TDP-43 pathology can be effective, suggesting that this approach may yield promising results.
Where this research is happening
-
University of Alabama at Birmingham
Birmingham, United States Active
Researchers
- Principal investigator: Andrabi, Shaida a. — University of Alabama at Birmingham
- Study coordinator: Andrabi, Shaida a.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.