Investigating how TDP-43 protein and hippocampal sclerosis affect Alzheimer's disease
Official title: Spatial Transcriptomics for Investigating the Interaction between TDP-43 Proteinopathy and Hippocampal Sclerosis in Alzheimer's Disease
Funded at University of Utah · NIH-10946790 · Data updated 2026-11-12
This study is looking at how certain brain changes related to Alzheimer's disease affect gene activity, which could help us understand the disease better and find new ways to treat it, and it's for anyone interested in the science behind Alzheimer's.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project start | September 15, 2024 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $242,290 |
| NIH project number | 1R21AG088509-01 |
| Project ID | NIH-10946790 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Alzheimer's disease who may also exhibit symptoms of hippocampal sclerosis or TDP-43 proteinopathy.
✕Less likely to help
Patients without a diagnosis of Alzheimer's disease or those who do not exhibit TDP-43 proteinopathy or hippocampal sclerosis may not benefit from this research.
What this research studies
This research explores the relationship between TDP-43 proteinopathy and hippocampal sclerosis in Alzheimer's disease by examining how these factors influence gene expression in the brain. Using advanced spatial transcriptomics techniques, the study aims to identify specific changes in RNA regulation associated with these conditions. Patients may benefit from insights gained about the molecular mechanisms underlying Alzheimer's, potentially leading to new therapeutic strategies. The research will involve analyzing brain tissue samples to understand the transcriptomic responses linked to these pathological features.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of Alzheimer's disease mechanisms and inform the development of targeted treatments.
How similar studies have gone: While the specific interplay of TDP-43 proteinopathy and hippocampal sclerosis in Alzheimer's disease is less explored, similar approaches in studying neurodegenerative diseases have shown promising results.
Where this research is happening
-
University of Utah
Salt Lake City, United States Active
Researchers
- Principal investigator: Mao, Qinwen — University of Utah
- Study coordinator: Mao, Qinwen
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.