Investigating how TDP-43 protein affects brain cell health in Alzheimer's and related dementias
Official title: Effects of TDP-43 Proteinopathy on Retrotransposon Activation and Cell-Type Specific Vulnerability in a Mammalian Model of Alzheimer's and Related Dementias
Funded at State University New York Stony Brook · NIH-10982507 · Data updated 2026-11-12
This study is looking at how a protein called TDP-43 might contribute to Alzheimer's disease by affecting brain cells and their health, using a special mouse model to help find new ways to treat the condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University New York Stony Brook NIH-funded |
| Lab location | 1 site (Stony Brook, United States) |
| Project start | December 1, 2022 |
| Project end | November 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $482,413 |
| NIH project number | 5R01AG079898-03 |
| Project ID | NIH-10982507 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or related dementias.
✕Less likely to help
Patients with other forms of dementia not related to Alzheimer's or those without neurodegenerative conditions may not benefit from this research.
What this research studies
This research explores the role of TDP-43 proteinopathy and retrotransposon activation in the development of Alzheimer's disease and related dementias using a mammalian model. The study aims to understand how TDP-43 toxicity can lead to neurodegeneration by activating retrotransposons in neurons and glial cells. Researchers will utilize a specific mouse model to investigate the effects of TDP-43 on brain cell interactions and the resulting impact on brain health. By examining these mechanisms, the research seeks to uncover potential pathways for therapeutic intervention.
Why it matters
Potential benefit: If successful, this research could lead to new insights and treatments for Alzheimer's disease and related dementias.
How similar studies have gone: Previous research has shown promising results in understanding the role of TDP-43 in neurodegeneration, suggesting that this approach could yield valuable insights.
Where this research is happening
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State University New York Stony Brook
Stony Brook, United States Active
Researchers
- Principal investigator: Sher, Roger B — State University New York Stony Brook
- Study coordinator: Sher, Roger B
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.